Urea kinetic modelling in two groups of patients on continuous ambulatory peritoneal dialysis - abstract
West Indian med. j
; West Indian med. j;44(Suppl. 2): 46, Apr. 1995.
Article
em En
| MedCarib
| ID: med-5720
Biblioteca responsável:
JM3.1
Localização: JM3.1; R18.W4
ABSTRACT
Dialysis adequacy (Kt/V) was investigated in two groups of patients on continuous ambulatory peritoneal dialysis (CAPD). Group I consisted of patients with serum creatinine 1200 umol/1 and above and Group II comprised patients with serum creatinine 600 umol/1 and less. The mean Kt/V was significantly higher in Group II (Kt/V, 2.0) compared to Group I (Kt/V, 1.59; p <0.01). The mean duration of CAPD dialysis was significantly longer in Group I (3.12 years) compared to Group II (1.32 years; p <0.01). Also, the mean total creatinine clearance for Group II was significantly higher than for Group I (p <0.001). There was good correlation between Kt/V and total creatinine clearance (r = 0.73; p <0.001); Kt/V and normalized protein catabolic rate (NPCR, r=0.6; p <0.001). There was weak correlation between Kt/V and duration on dialysis, but this was statistically significant. There was no difference between mean NPCR and mean mid-arm muscle circumference (MAMC) in the two groups and no significant association between Kt/V and NAMC. Group II patients had a significantly better residual renal clearance (p <0.0001). Pruritus was a troublesome feature in Group I, but in both groups patients were distressed by loss of libido, insomnia and tiredness. This study revealed that Group II patients with lower creatinine had better dialysis adequacy but were on CAPD for a shorter duration than Group I and had significantly better residual renal clearance and total clearance. Muscle mass does not appear to have contributed significantly to the differences in creatinine between the groups. Additional studies on peritoneal membrane function vis-a-vis solute transfer need to be done on these patients (AU)
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Coleções:
01-internacional
Base de dados:
MedCarib
Assunto principal:
Ureia
/
Diálise Peritoneal Ambulatorial Contínua
Limite:
Humans
Idioma:
En
Revista:
West Indian med. j
Ano de publicação:
1995
Tipo de documento:
Article
/
Congress and conference