Haploptyes of ás chromosomes and O gene status among patients with sickle-cell disease in Guadeloupe - abstract
West Indian med. j
; West Indian med. j;39(Suppl. 1): 57, Apr. 1990.
Article
em En
| MedCarib
| ID: med-5256
Biblioteca responsável:
JM3.1
Localização: JM3.1; R18.W4
ABSTRACT
A sample of 42 unrelated sickle cell (SS) patients were randomly selected from regular attenders at the paediatric services of the Pointe-a-Pitre Hospital. á gene cluster and O gene haplotypes were determined by Southern blotting. Twelve á haplotypes in 12 combinations were found for the 84 ás chromosomes studied. The most common were Benin (63 per cent), Bantu (12 per cent) and Senegal (11 per cent) types which accounted for 87 per cent of all chromosomes. About 13 per cent of the ás chromosomes analysed had atypical haplotypes. Much the same diversity was observed for the ás gene in Jamaicans and Black patients in the USA. An interesting feature was the high (46 per cent) gene frequency of deletional O thalassemia. One patient had the O gene globin triplication. The frequency of (-O) was 0.24, and there is no evidence that this frequency differs from one á-haplotype to another. No clear correlations could be made between the haemoglobin level, haematological parameters and á haplotype status in this study because of the large number of variables and small sample size. From the anthropological aspect, haplotyping may shed light on the slave trade from various parts of Africa to the Caribbean (AU)
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Coleções:
01-internacional
Base de dados:
MedCarib
Assunto principal:
Haplótipos
/
Anemia Falciforme
Limite:
Humans
País/Região como assunto:
Guadalupe
Idioma:
En
Revista:
West Indian med. j
Ano de publicação:
1990
Tipo de documento:
Article
/
Congress and conference