Human T-cell lymphotropic virus type I and severe neoplasia of the cervix in Jamaica
Int J Cancer
; 61(1): 23-6, 1995.
Article
em En
| MedCarib
| ID: med-5033
Biblioteca responsável:
JM3.1
Localização: JM3.1; Reprint Collection
ABSTRACT
Human T-cell lymphotropic virus type I (HTLV-I) was associated with carcinoma of the cervix in Japan in a recent study that compared hospital cases with healthy population-based controls. To test this relationship in women more alike for cervical neoplasia risk factors (including sexual behavior and human papilloma virus HPV), we enrolled consecutive patients from a colposcopy clinic in Kingston, Jamaica (an HTLV-1 endemic area). Patients underwent Pap smear, calopscopy, biopsy and cervical swab for detection of HPV by polymerase chain reaction. Cases were defined as women with CIN-3 or invasive cancer (CIN-3/CA). Controls included all patients with either CIN-1 or koilocytotic atypia, atypical squamous cells of undetermined significane or benign cervical pathology (all but one had at least inflammatory changes). Patients with CIN-2 were excluded to minimize risk of case-control misclassification. Cases were much more likely to be HTLV-1 seropositive than controls. Although mean age differed significantly between cases (mean age = 39 years) and controls (mean age = 33 years), control for age did not explain the relation of CIN-3/CA with HTLV-1. Among HPV DNA positive subjects the age-adjusted association was not diminished but lost statistical significance. HTLV-1 seroprevalence may be independently associated with progression to severe neoplasia of the cervix (AU)
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Coleções:
01-internacional
Base de dados:
MedCarib
Assunto principal:
Vírus Linfotrópico T Tipo 1 Humano
/
Anticorpos Anti-HTLV-I
/
Infecções por HTLV-I
/
Doenças do Colo do Útero
/
Neoplasias do Colo do Útero
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
País/Região como assunto:
Asia
/
Caribe ingles
/
Jamaica
Idioma:
En
Revista:
Int J Cancer
Ano de publicação:
1995
Tipo de documento:
Article