Photosensitivity and antinuclear antibodies in black patients with systemic lupus erythematosus
J Assoc Acad Minor
; 7(2): 53-5, 1996.
Article
em En
| MedCarib
| ID: med-2379
Biblioteca responsável:
JM3.1
Localização: JM3.1; Reprint collection
ABSTRACT
Black patients with systemic lupus erythematosus (SLE) have a lower prevalence of photosensitivity rashes than white patients. The reasons for this are unkown, but some studies suggest a correlation between the presence of antinuclear antibodies and protection from phosensitivity. In our study, we determined serum antinuclear-antibody profiles, including anti-dsDNA, anti-Sm, anti-RNP, anti-Ro/SS-A, anti-La/SS-B antibodies, in 91 black Jamaican patients with SLE. All 91 serum samples from SLE patients (100 percent) were positive in the fluorescent antinuclear-antibody test. Using the crithidia luciliae immunofluorescence test, anti-dsDNA was found in 27.5 percent of the samples. By a double immunodiffusion method, anti-Sm antibodies were found in 15.4 percent, and anti-RNP in 18.7 percent, anti-Ro/SS-A in 9.9 percent and anti-La/SS-B in 11.0 percent. However, no statistically significant differences were observed in the seroprevalence of these antinuclear antibodies when sera from patients of the following groups were compared only photosensitivity rashes (n = 17), photosensitivity and other rashes (n = 23), other rashes without photosensitivity (n = 27), and patients with no skin rash of any type (n = 24). These results suggest that photosensitivity in black Jamaican patients with SLE is not associated with antinuclear-antibody specificity(AU)
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Coleções:
01-internacional
Base de dados:
MedCarib
Assunto principal:
Lúpus Eritematoso Cutâneo
/
Anticorpos Antinucleares
/
Dermatite Fotoalérgica
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Aged
/
Child
/
Female
/
Humans
/
Male
País/Região como assunto:
Caribe ingles
/
Jamaica
Idioma:
En
Revista:
J Assoc Acad Minor
Ano de publicação:
1996
Tipo de documento:
Article