Linkage of asthma and total serum IgE concentration to markers on chromosome 12q: evidence from Afro-Caribbean and Caucasian population
Genomics
; 37(1): 41-50, Oct. 1, 1996.
Article
em En
| MedCarib
| ID: med-2132
Biblioteca responsável:
JM3.1
Localização: JM3.1
ABSTRACT
To identify genes potentially relevant in atopic asthma, we analyzed markers in chromosome 12q15-q24.1 for linkage to asthma and total serum Ige concentration. Sib-pair analyses of 10 markers in 345 full- and 219 half-sib pairs from 29 multiplex Afro-Caribbean families provided evidence for linkage to his region for both asthma and total serum IgE. Certain alleles at these loci showed significant evidence of transmission disequilibrium with both asthma and high IgE. Using 6 of these markers and 11 additional markers, evidence for linkage of total IgE to 12q was also found in 12 Caucasian Amish kindreds (24 nuclear families) by both sib-pair and transmission disequilibrium analyses. These findings suggest that the 12q15-q24.1 region may contain a gene(s) contolling asthma and the associated high total IgE. trait.(AU)
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Coleções:
01-internacional
Base de dados:
MedCarib
Assunto principal:
Asma
/
Cromossomos Humanos Par 12
/
Imunoglobulina E
/
Ligação Genética
Tipo de estudo:
Prognostic_studies
Limite:
Adolescent
/
Adult
/
Aged
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
País/Região como assunto:
Caribe
Idioma:
En
Revista:
Genomics
Ano de publicação:
1996
Tipo de documento:
Article