Cardiovascular disease and oral contraception: what more can we learn from epidemiologic studies?
Adv Contracept
; 7(suppl.3): 65-83, 1991.
Article
em En
| MedCarib
| ID: med-2018
Biblioteca responsável:
JM3.1
Localização: JM3.1; Reprint collection
ABSTRACT
Many epidemiologic investigations including case-control and cohort studies have attempted to evaluate the association between the use of oral contraceptives and cardiovascular disease. These studies were largely carried out over a decade ago and in general demonstrated that oral contraceptive use did increase the risk of various diseases. The majority of these studies had insufficient power however, to evaluate several critical associated questions including the optimal composition, dosage and duration of the oral contraceptive used, and currently available data are often inconsistent and conflicting. Since the majority of these epidemiologic studies were carried out, contraceptive practices have changed, as has the composition and dosages of the drugs used. In attempt to evaluate the risks associated with current prescribing practices using currently available oral contraceptives amongst women from all around the world, (hiherto virtually no data are available from outside Europe and the USA) an international multicenter case-control study was begun in 1989. The potential for this study to supply the answers to the many important outstanding questions is discussed. Assumig strict attention to good methodology and study design, very large studies are required to provide many of the missing answers. (AU)
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Coleções:
01-internacional
Base de dados:
MedCarib
Assunto principal:
Doenças Cardiovasculares
/
Anticoncepcionais Orais
Tipo de estudo:
Clinical_trials
/
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adult
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Female
/
Humans
Idioma:
En
Revista:
Adv Contracept
Ano de publicação:
1991
Tipo de documento:
Article