Hepatitis B associated nephrotic syndrome in Jamaican children: a 12 year review
West Indian med. j
; 47(suppl. 2): 50, Apr. 1998.
Article
em En
| MedCarib
| ID: med-1830
Biblioteca responsável:
JM3.1
Localização: JM3.1; R18.W4
ABSTRACT
Between December 1984 and November 1996, 171 children under 12 years of age presented to the University Hospital of the West Indies with nephrotic syndrome. Of these, 10 were diagnosed hepatitis B surface antigen (HbsAg) positive on routine screening. Their clinicopathological data were analyzed and renal histology documented. Eight of the ten children had membranous nephropathy (MN), while the remainder had mesangial proliferative glomerulonephritis (MesN) and minimal change nephrotic syndrome (MCNs). The young ages and steroid sensitivity of these two children suggested that hepatitis B virus (HBV) infection was coincidental rather than causative. Steroids were ineffective in inducing remission in any of the 4 MN patients so treated. At a mean follow-up of 36 months, 7/10 patients had experienced complete or partial remission and 3 had persistent nephrotic syndrome. None was in renal failure and 60 percent had asymptomatic biochemical hepatitis. Remission occurred in the MN group either 2 to 9 months from the onset of oedema whether or not steroids were administered. Our data suggest that the prevalence of HBV infection in Jamaica may be intermediate rather than low and that the route of transmission may be horizontal. It is recommended that hepatitis B vaccination be a part of the regular immunization in Jamaica, and that all children with nephrotic or atypical glomerular disease be screened for HbsAg as HBV nephropathy is usually clinically indistinguishable from idiopathic renal disease.(AU)
Buscar no Google
Coleções:
01-internacional
Base de dados:
MedCarib
Assunto principal:
Hepatite B
/
Síndrome Nefrótica
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Child
/
Child, preschool
/
Humans
País/Região como assunto:
Caribe ingles
/
Jamaica
Idioma:
En
Revista:
West Indian med. j
Ano de publicação:
1998
Tipo de documento:
Article