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Plasma homocysteine is elevated in COPD patients and is related to COPD severity.
Seemungal, Terence ; Lun, Johanna Cho Fook; Davis, Gershwin ; Neblett, Carlos ; Chinyepi, Nkhabe ; Dookhan, Christina ; Drakes, Samantha ; Mandeville, Elizabeth ; Nana, Fatima ; Setlhake, Seatshogeng ; Poon-King, Celia ; Pereira, Lexley Pinto ; Delisle, Jerome ; Wilkinson, Thomas MA ; Wedzicha, Jagwiga .
Afiliação
  • Seemungal, Terence ; The University of the West Indies. Faculty of Medical Sciences. Departments of Clinical Medical Sciences. St. Augustine. Trinidad and Tobago
  • Lun, Johanna Cho Fook; The University of the West Indies. Faculty of Medical Sciences. Departments of Clinical Medical Sciences. St. Augustine. Trinidad and Tobago
  • Davis, Gershwin ; The University of the West Indies. Faculty of Medical Sciences. Paraclinical Sciences. St. Augustine. Trinidad and Tobago
  • Neblett, Carlos ; The University of the West Indies. Faculty of Medical Sciences. Departments of Clinical Medical Sciences. St. Augustine. Trinidad and Tobago
  • Chinyepi, Nkhabe ; The University of the West Indies. Faculty of Medical Sciences. Departments of Clinical Medical Sciences. St. Augustine. Trinidad and Tobago
  • Dookhan, Christina ; The University of the West Indies. Faculty of Medical Sciences. Departments of Clinical Medical Sciences. St. Augustine. Trinidad and Tobago
  • Drakes, Samantha ; The University of the West Indies. Faculty of Medical Sciences. Departments of Clinical Medical Sciences. St. Augustine. Trinidad and Tobago
  • Mandeville, Elizabeth ; The University of the West Indies. Faculty of Medical Sciences. Departments of Clinical Medical Sciences. St. Augustine. Trinidad and Tobago
  • Nana, Fatima ; The University of the West Indies. Faculty of Medical Sciences. Departments of Clinical Medical Sciences. St. Augustine. Trinidad and Tobago
  • Setlhake, Seatshogeng ; The University of the West Indies. Faculty of Medical Sciences. Departments of Clinical Medical Sciences. St. Augustine. Trinidad and Tobago
  • Poon-King, Celia ; The University of the West Indies. Faculty of Medical Sciences. Paraclinical Sciences. St. Augustine. Trinidad and Tobago
  • Pereira, Lexley Pinto ; The University of the West Indies. Faculty of Medical Sciences. Paraclinical Sciences. St. Augustine. Trinidad and Tobago
  • Delisle, Jerome ; The University of the West Indies. Faculty of Medical Sciences. Centre for Medical Sciences Education. St. Augustine. Trinidad and Tobago
  • Wilkinson, Thomas MA ; University College London. University College Medical School. Academic Unit of Respiratory Medicine. London. England
  • Wedzicha, Jagwiga ; University College London. University College Medical School. Academic Unit of Respiratory Medicine. London. England
International journal of chronic obstructive pulmonary disease ; 2(3): 313-321, Oct 2007. tabgraf
Article em En | MedCarib | ID: med-17741
Biblioteca responsável: TT5
ABSTRACT

BACKGROUND:

Although recent studies have found that total plasma homocysteine (tHCY) and chronic obstructive pulmonary disease (COPD) are both risk factors for cardiac disease, there have been few studies of plasma homocysteine levels in COPD patients. We tested the hypothesis that total plasma homocysteine (tHCY) would be elevated in patients diagnosed with COPD compared with controls.

METHODS:

We studied 29 COPD outpatients and 25 asymptomatic subjects (controls) over age 55 years with measurement of forced expiratory volume in one second (FEV1), forced vital capacity (FVC), St. Georges Respiratory Questionnaire (SGRQ) score, tHCY and serum C-reactive protein (sCRP).

RESULTS:

There was no difference between controls vs. COPD patients in mean age or gender but mean (SD) FEV1 was 2.25 (0.77) vs. 1.43 (0.60) L; FEV1 per cent predicted 76.1 (17.2) vs. 49.1 (16.3) p < 0.001 in both cases. Median (IQR) tHCY was 8.22 (6.63, 9.55) in controls vs. 10.96 (7.56, 13.60) micromol/l for COPD, p = 0.006 and sCRP 0.89 (0.47, 2.55) vs. 2.05 (0.86, 6.19) mg/l, p = 0.023. tHCY(log) was also higher in (r, p) smokers (0.448, 0.001), patients with low FEV1 per cent (-0.397, 0.003), males (0.475, < 0.001), but high SGRQ Total score (0.289, 0.034), and high sCRP (0.316, 0.038). tHCY(log) was independently related to (regression coefficient, p) sCRP(log) (0.087, 0.024), male gender (0.345, < 0.001) and presence of COPD (0.194, 0.031). Median (IQR) tHCY GOLD Stage I and II 8.05 (7.28, 11.04), GOLD Stage III and IV 11.83 (9.30, 18.30); p = 0.023.

CONCLUSIONS:

Plasma homocysteine is significantly elevated in COPD patients relative to age and sex-matched controls and is related to serum CRP and COPD severity.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MedCarib Assunto principal: Trinidad e Tobago / Proteína C-Reativa / Volume Expiratório Forçado / Doença Pulmonar Obstrutiva Crônica / Homocisteína Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adult / Humans País/Região como assunto: Caribe ingles / Trinidad y tobago Idioma: En Revista: International journal of chronic obstructive pulmonary disease Ano de publicação: 2007 Tipo de documento: Article
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google
Texto completo: 1 Coleções: 01-internacional Base de dados: MedCarib Assunto principal: Trinidad e Tobago / Proteína C-Reativa / Volume Expiratório Forçado / Doença Pulmonar Obstrutiva Crônica / Homocisteína Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adult / Humans País/Região como assunto: Caribe ingles / Trinidad y tobago Idioma: En Revista: International journal of chronic obstructive pulmonary disease Ano de publicação: 2007 Tipo de documento: Article