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Determination of RBC membrane and serum lipid composition in Trinidadian type II diabetics with and without nephropathy.
Nayak, Shivananda B. ; Beharry, Vishi Y. ; Armoogam, Shivani ; Nancoo, Melinda ; Ramadhin, Kevin ; Ramesar, Kiron ; Ramnarine, Ciara ; Singh, Anandi; Singh, Anisha ; Nwachi, Kingsley Uche ; Teelucksing, Surujpaul ; Mathura, Ramesh ; Roberts, Lesley .
Afiliação
  • Nayak, Shivananda B. ; University of the West Indies. Faculty of Medical Sciences. Department of Preclinical Sciences. St. Augustine. Trinidad and Tobago
  • Beharry, Vishi Y. ; University of the West Indies. Faculty of Medical Sciences. Department of Preclinical Sciences. St. Augustine. Trinidad and Tobago
  • Armoogam, Shivani ; University of the West Indies. Faculty of Medical Sciences. Department of Preclinical Sciences. St. Augustine. Trinidad and Tobago
  • Nancoo, Melinda ; University of the West Indies. Faculty of Medical Sciences. Department of Preclinical Sciences. St. Augustine. Trinidad and Tobago
  • Ramadhin, Kevin ; University of the West Indies. Faculty of Medical Sciences. Department of Preclinical Sciences. St. Augustine. Trinidad and Tobago
  • Ramesar, Kiron ; University of the West Indies. Faculty of Medical Sciences. Department of Preclinical Sciences. St. Augustine. Trinidad and Tobago
  • Ramnarine, Ciara ; University of the West Indies. Faculty of Medical Sciences. Department of Preclinical Sciences. St. Augustine. Trinidad and Tobago
  • Singh, Anandi; University of the West Indies. Faculty of Medical Sciences. Department of Preclinical Sciences. St. Augustine. Trinidad and Tobago
  • Singh, Anisha ; University of the West Indies. Faculty of Medical Sciences. Department of Preclinical Sciences. St. Augustine. Trinidad and Tobago
  • Nwachi, Kingsley Uche ; University of the West Indies. Faculty of Medical Sciences. Department of Preclinical Sciences. St. Augustine. Trinidad and Tobago
  • Teelucksing, Surujpaul ; University of the West Indies. Faculty of Medical Sciences. Department of Clinical Science. St. Augustine. Trinidad and Tobago
  • Mathura, Ramesh ; Eric Williams Medical Sciences Complex. North Central Regional Health Authority. Department of Diagnostic Laboratory Services. Champs Fleurs. Trinidad and Tobago
  • Roberts, Lesley ; Eric Williams Medical Sciences Complex. North Central Regional Health Authority. Department of Medicine, Nephrology Unit. Champs Fleurs. Trinidad and Tobago
Vascular health and risk management ; 4(4): 893-899, Aug 2008. graftab
Article em En | MedCarib | ID: med-17720
Biblioteca responsável: TT5
ABSTRACT

AIM:

The rheological properties of erythrocytes are impaired in diabetes mellitus, especially because of changes in their membrane lipid composition.The aim of this study was to determine and examine the relationship between red blood cell (RBC) membrane and serum lipid composition in type II diabetes subjects with and without nephropathy.

METHODS:

Trinidadian subjects aged 18-65 years were recruited for the study regardless of gender and ethnicity. Fasting blood samples were collected from 60 subjects of whom 20 were healthy individuals, 20 had type II diabetes without complications, and 20 were type II diabetics with nephropathy. Weight, height, waist/hip ratio, and blood pressure were recorded. All the blood samples were analysed to determine the serum lipid concentration, membrane lipid composition and plasma glucose concentration.

RESULTS:

The body mass index and the systolic blood pressure of the diabetics (28.17 +/- 4.98 kg/m2, 153.21 +/- 22.10 mmHg) and those with nephropathy (25.87 +/- 4.68, 158.60 +/- 22.49 mmHg) were higher when compared with controls (24.67 +/- 5.18, 119.15 +/- 13.03 mmHg). The diabetic (175.89 +/- 102.73 microg/mgprotein) and diabetic nephropathy (358.80 +/- 262.66) subjects showed significantly higher levels of RBC membrane cholesterol compared with controls (132.27 +/- 66.47). The membrane phospholipids, protein and Na+/K+ATPase concentrations were altered in diabetics and diabetic nephropathy patients when compared with controls. The trends of increased serum cholesterol and decreased high-density lipoprotein in diabetics and diabetic nephropathy patients were noted as compared with controls but they are not significant as expected. The low-density lipoprotein cholesterol was significantly higher in diabetics when compared with diabetic nephropathy and control subjects.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MedCarib Assunto principal: Fosfolipídeos / Trinidad e Tobago / Proteínas / Diabetes Mellitus Tipo 2 / Membrana Eritrocítica Limite: Humans País/Região como assunto: Caribe ingles / Trinidad y tobago Idioma: En Revista: Vascular health and risk management Ano de publicação: 2008 Tipo de documento: Article
Texto completo
Adicionar na Minha BVS
Imprimir
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Buscar no Google
Texto completo: 1 Coleções: 01-internacional Base de dados: MedCarib Assunto principal: Fosfolipídeos / Trinidad e Tobago / Proteínas / Diabetes Mellitus Tipo 2 / Membrana Eritrocítica Limite: Humans País/Região como assunto: Caribe ingles / Trinidad y tobago Idioma: En Revista: Vascular health and risk management Ano de publicação: 2008 Tipo de documento: Article