Evaluation of the wound-healing activity of ethanolic extract of morinda citrifolia L. Leaf.
Evidence-based complementary and alternative medicine
; 4: [], Oct 2007. grafilus
Article
em En
| MedCarib
| ID: med-17715
Biblioteca responsável:
TT5
ABSTRACT
Morinda citrifolia L. (noni) is one of the most important traditional Polynesian medicinal plants. The primary indigenous use of this plant appears to be of the leaves, as a topical treatment for wound healing. The ethanol extract of noni leaves (150 mg kg(-1) day(-1)) was used to evaluate the wound-healing activity on rats, using excision and dead space wound models. Animals were randomly divided into two groups of six for each model. Test group animals in each model were treated with the ethanol extract of noni orally by mixing in drinking water and the control group animals were maintained with plain drinking water. Healing was assessed by the rate of wound contraction, time until complete epithelialization, granulation tissue weight and hydoxyproline content. On day 11, the extract-treated animals exhibited 71 per cent reduction in the wound area when compared with controls which exhibited 57 per cent. The granulation tissue weight and hydroxyproline content in the dead space wounds were also increased significantly in noni-treated animals compared with controls (P < 0.002). Enhanced wound contraction, decreased epithelialization time, increased hydroxyproline content and histological characteristics suggest that noni leaf extract may have therapeutic benefits in wound healing.
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Coleções:
01-internacional
Base de dados:
MedCarib
Assunto principal:
Trinidad e Tobago
/
Cicatrização
/
Morinda
Tipo de estudo:
Prognostic_studies
País/Região como assunto:
Caribe ingles
/
Trinidad y tobago
Idioma:
En
Revista:
Evidence-based complementary and alternative medicine
Ano de publicação:
2007
Tipo de documento:
Article