The ¢ ligand 1, 3-di-o-tolylguanidine depresses amino acid-induced exitation non-selectively in rat brain

Connick, Jonathan H; Addae, Jonas I; Nicholson, C. David; Stone, Trevor W

Connick, Jonathan H; Addae, Jonas I; Nicholson, C. David; Stone, Trevor W.

Afiliação

Connick, Jonathan H; Organon Laboratories Ltd. Department of Pharmacology. Newhouse, Lanarkshire. United Kingdom
Addae, Jonas I; The University of the West Indies. Department of Physiology. St. Augustine. Trinidad and Tobago
Nicholson, C. David; Department of Pharmacology. Organon Laboratories Ltd. Newhouse, Lanarkshire. United Kingdom
Stone, Trevor W; University of Glasgow. Department of Pharmacology. Glasgow. United Kingdon

Eur. j. pharmacol ; Eur. j. pharmacol;214(2/3): 169-173, Apr. 1992. ilus

Article em En | MedCarib | ID: med-17102

Biblioteca responsável: TT5

Localização: TT5; W1 EU72E

ABSTRACT

ABSTRACT

The ¢ ligand 1, 3-di-o-tolylguanidine (DTG) has been applied by microiontophoresis to neurones in the rat hippocampal slice and to neurones in the neocortex and hippocampus of rats anaesthetised with urethane. DTG depressed the excitatory responses of cells to both N-methyl-D-aspartate (NMDA) and quisqualate on a majority of the units tested, in no case causing an enhancement. Haloperidol had no consistent effect of its own and did not prevent the depressant effects of DTG. It is concluded that in the preparations used, DTG did not selectively modify neuronal sensitivity to NMDA (AU)

Assuntos

Animais; Ratos; Hipocampo/efeitos dos fármacos; N-Metilaspartato/análise; N-Metilaspartato/efeitos dos fármacos; Haloperidol/análise; Haloperidol

Buscar no Google

Adicionar na Minha BVS

Imprimir

XML

Coleções: 01-internacional Base de dados: MedCarib Assunto principal: N-Metilaspartato / Haloperidol / Hipocampo Limite: Animals Idioma: En Revista: Eur. j. pharmacol Ano de publicação: 1992 Tipo de documento: Article

Buscar no Google

Adicionar na Minha BVS

Imprimir

XML