An experimental study of pulmonary damage associated with intravenous injection of halothane in dogs
Br J Anaesth
; 42(5): 419-24, May 1970.
Article
em En
| MedCarib
| ID: med-14721
Biblioteca responsável:
JM3.1
Localização: JM3.1; RD79.A1B7
ABSTRACT
Holothane was injected intravenously into two groups of dogs and the effects on the lungs noted. The nine dogs of group I were unanaesthetized and received no ventilatory support following injection. The dogs were killed at varying time intervals after injection and the macroscopic and microscopic appearances were studied. In the six dogs of group II the the chests were open and they were artificially ventilated with 30 per cent oxygen and 70 per cent nitrous oxide at the time of injection. Serial biopsies were taken. The predominant lesions produced were generalized oedema and patchy alveolar haemorrhages. These changes were more severe in dogs of group I. The aetiology is conjectural, possibly being due to direct capillary damage or to embolization. The danger of accidental intravenous injection of halothane, a not unknown occurrence, is stressed (AU)
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Coleções:
01-internacional
Base de dados:
MedCarib
Assunto principal:
Halotano
/
Pulmão
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
Idioma:
En
Revista:
Br J Anaesth
Ano de publicação:
1970
Tipo de documento:
Article