Studies on the effect of diet on hepatic lipogenesis
Kingston; Mar. 1959. iii,128 p. tab.
Thesis
em En
| MedCarib
| ID: med-13753
Biblioteca responsável:
JM23.1
Localização: JM23.1; U Thesis
ABSTRACT
This thesis is an account of investigation in which special diets were fed to rats and the resulting effects on hepatic lipogenesis studied. The carbohydrate and fat contents of the diets were varied and groups of rats on the different diets compared. It was shown in a test system consisting of liver slices that rats, which were previously fed for two days on a relatively high carbohydrate diet, incorporated the carbon of 14C labelled glucose into fatty acids and carbon dioxide at an increased rate when compared with rats fed a relatively low and a control diet. Hepatic glucose - 6 - phosphatase activity was not altered by feeding the different diets. Liver glycogen concentrations was also unaltered. The ratio of this concentrations of oxidised to reduced diphosphopyridine nucleotide in liver was higher for rats on the "high" carbohydrate diet than for rats on the "low" carbohydrate and the control diets. The concentration of reduced triphosphopyridine nucleotide in liver was decreased by feeding the "high" carbohydrate diet. The plasma "insulin activity" of the rats on the "high" carbohydrate diet was less than that of rats on the "low" carbohydrate diet. There was no significant difference between the "insulin binding" capacity of the livers of rats fed the "high" and "low" carbohydrate diets. It was not possible to offer any explanation, from the experimental results, of how the "high" carbohydrate diet caused an increase in hepatic lipogenesis (AU)
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Coleções:
01-internacional
Base de dados:
MedCarib
Assunto principal:
Fígado
Limite:
Animals
Idioma:
En
Ano de publicação:
1959
Tipo de documento:
Thesis
País de publicação:
Jamaica