Jamaican vomiting sickness: biochemical investigation of two cases
N Engl J Med
; 295(9): 461-7, Aug. 1976.
Article
em En
| MedCarib
| ID: med-13116
Biblioteca responsável:
JM3.1
Localização: JM3.1; R11.N4
ABSTRACT
We identified methylenecyclopropylacetic acid, a known metabolite of hypoglycin A, in the urine of two patients with Jamaican vomiting sickness. Excretion of unusual dicarboxylic acids such as 2-ethylmalonic, 2-methylsuccinic, glutaric, adipic and dicarboxylic acids with eight and 10 carbon chains were also detected in both patients. The amounts of these dicarboxylic acids were 70 to 1000 times higher than normal. These metabolities have also been identified in urine of hypoglycin-treated rats. This evidence links hypoglycin A to Jamaican vomiting sickness as its causative agent. Urinary excretion of short-chain fatty acids was also increased up to 300 times higher than normal. These results indicate that, despite their clinical and histological similarities, the cause and biochemical mechanisms of Jamaican vomiting sickness differ distinctly from those of Reye's syndrome in which these abnormal urinary metabolities are not appreciably increased.(AU)
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Coleções:
01-internacional
Base de dados:
MedCarib
Assunto principal:
Intoxicação por Plantas
/
Vômito
/
Hipoglicinas
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Prognostic_studies
Limite:
Animals
/
Child, preschool
/
Female
/
Humans
País/Região como assunto:
Caribe ingles
/
Jamaica
Idioma:
En
Revista:
N Engl J Med
Ano de publicação:
1976
Tipo de documento:
Article