Alpha-thalassemia in a selected population of Mexico.
Rev Invest Clin
; 50(5): 395-8, 1998.
Article
em En
| MEDLINE
| ID: mdl-9949669
OBJECTIVE: To identify by molecular biology the alleles of alpha-Thal in selected hospital populations. METHODS: Eighteen propositi with hematological and biochemical data suggestive of alpha-thalassemia, selected from 356 patients of four hospitals in two cities with probable hemoglobinopathy were investigated for six common alpha-Thal alleles. Molecular studies were done by PCR and digestion with specific restriction enzymes. RESULTS: The alpha 3.7 allele was identified in two cases and the family study revealed the same allele in the mother; HbS heterozigocity was also detected in one of them. An analysis with Apa I demonstrated a class I deletion in both patients. The present study showed 2/356 (0.6%) of alpha 3.71 carriers which is a low frequency as compared with other countries. As no other common alpha-thalassemia alleles were found, we suspect that alpha-Thal in Mexico is as heterogeneous at a molecular level as beta-Thal.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Talassemia alfa
Limite:
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
País/Região como assunto:
Mexico
Idioma:
En
Revista:
Rev Invest Clin
Assunto da revista:
MEDICINA
Ano de publicação:
1998
Tipo de documento:
Article
País de publicação:
México