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Effects of accumbens m-chlorophenylbiguanide microinjections on sleep and waking in intact and 6-hydroxydopamine-treated rats.
Monti, J M; Ponzoni, A; Jantos, H; Lagos, P; Silveira, R; Banchero, P.
Afiliação
  • Monti JM; Department of Pharmacology and Therapeutics, School of Medicine, Clinics Hospital, Montevideo, Uruguay. jmonti@chasque.apc.org
Eur J Pharmacol ; 364(2-3): 89-98, 1999 Jan 08.
Article em En | MEDLINE | ID: mdl-9932710
Effects of the 5-HT3 receptor agonist, m-chlorophenylbiguanide (10.0-40.0 microg), on sleep and waking were studied in control, vehicle-treated and 6-hydroxydopamine-injected rats. Bilateral injections of m-chlorophenylbiguanide into the nucleus accumbens of the control and the vehicle-infused animals significantly increased waking and reduced slow wave sleep. Rapid eye movement sleep (REM sleep) remained unchanged. Pretreatment with the selective 5-HT3 receptor antagonist, MDL 72222 (1aH,3a,5a, H-tropan-3-yl-3,5-dichloro-benzoate) (0.5 mg/kg, s.c.), reversed the effects of m-chlorophenylbiguanide (10.0-20.0 microg) on sleep and waking in the control group. Administration of the 5-HT3 receptor agonist to the 6-hydroxydopamine-treated animals modified only slightly the time spent in wakefulness and slow wave sleep, while REM sleep was significantly and dose dependently reduced. Our findings further support the proposal that increase of wakefulness and reduction of slow wave sleep after activation of 5-HT3 receptors, is partly related to the release of endogenous dopamine.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sono / Vigília / Biguanidas / Oxidopamina / Agonistas do Receptor de Serotonina / Núcleo Accumbens Limite: Animals Idioma: En Revista: Eur J Pharmacol Ano de publicação: 1999 Tipo de documento: Article País de afiliação: Uruguai País de publicação: Holanda
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sono / Vigília / Biguanidas / Oxidopamina / Agonistas do Receptor de Serotonina / Núcleo Accumbens Limite: Animals Idioma: En Revista: Eur J Pharmacol Ano de publicação: 1999 Tipo de documento: Article País de afiliação: Uruguai País de publicação: Holanda