Zinc sulphate in the treatment of cutaneous leishmaniasis: an in vitro and animal study.
Mem Inst Oswaldo Cruz
; 93(6): 831-7, 1998.
Article
em En
| MEDLINE
| ID: mdl-9921312
This study was designed to evaluate the effectiveness of zinc sulphate both in vitro and in an animal model against both strains of old world cutaneous leishmaniasis. The in vitro sensitivities of promastigotes and axenic amastigotes of both Leishmania major and L. tropica to zinc sulphate was determined, the LD50 calculated and compared to the standard treatment for cutaneous leishmaniasis pentavalent antimony compounds. The results show that the two forms of both strains were sensitive to zinc sulphate and their respective LD50 were lower compared to the pentavalent antimony compound. Furthermore the sensitivities of the forms of both strains were tested using a simple slide method and compared to results of the standard method. To confirm this result, zinc sulphate was administered orally to mice infected with cutaneous leishmaniasis both therapeutically and prophylactically. Results showed that oral zinc sulphate was effective in both treatment and prophylaxis for cutaneous leishmaniasis. These results encourage the use of oral zinc sulphate in the treatment of cutaneous leishmaniasis clinically.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Leishmania tropica
/
Leishmaniose Cutânea
/
Leishmania major
/
Sulfato de Zinco
Limite:
Animals
Idioma:
En
Revista:
Mem Inst Oswaldo Cruz
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Iraque
País de publicação:
Brasil