Contraception with two levonorgestrel rod implants. A 5-year study in the United States and Dominican Republic.
Contraception
; 58(5): 275-82, 1998 Nov.
Article
em En
| MEDLINE
| ID: mdl-9883382
ABSTRACT
PIP: The newly developed 2-rod levonorgestrel (LNG) implant system has a surface area only 44% that of Norplant yet provides LNG release rates and blood levels similar to the 6-capsule Norplant system. Clinical trials of the 2-rod implant system initiated in 1990 demonstrated an exceptionally low cumulative pregnancy rate (0.8/100) in the first 3 years of use. This paper reports on an extension of the original study for an additional 2 years. 594 women at 4 study sites in the US and the Dominican Republic completed 5 years of method use. No pregnancies occurred in the fourth and fifth years of use. Thus, the 5-year cumulative pregnancy rate was 0.8/100, with an average annual pregnancy rate below 2/1000 women. The mean annual continuation rate during the 5-year study period was 77/100 women, with an average duration of use of 2.96 years. The most frequent reasons for medical removal were prolonged bleeding/spotting (8.2% of women), irregular bleeding (5.6%), headache (4.7%), and weight gain (4.0%). Mean removal time was 5.9 minutes and complications occurred in only 2.3% of removals. Overall, these findings confirm that the 2-rod LNG implant contraceptive has an effectiveness equivalent to the 6-capsule implant for a 5-year period, with good acceptability and a substantially improved ease of removal.
Palavras-chave
Americas; Caribbean; Contraception; Contraception Continuation; Contraception Research; Contraceptive Agents, Female--pharmacodynamics; Contraceptive Agents, Progestin--pharmacodynamics; Contraceptive Agents--pharmacodynamics; Contraceptive Effectiveness; Contraceptive Implants; Contraceptive Methods; Contraceptive Removal; Contraceptive Usage; Developed Countries; Developing Countries; Dominican Republic; Family Planning; Latin America; Levonorgestrel--pharmacodynamics; North America; Northern America; Prospective Studies; Research Methodology; Research Report; Studies; Treatment; United States
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Levanogestrel
/
Anticoncepcionais Femininos
Tipo de estudo:
Clinical_trials
/
Etiology_studies
Limite:
Adolescent
/
Adult
/
Female
/
Humans
/
Pregnancy
País/Região como assunto:
America do norte
/
Caribe ingles
/
Dominica
/
Republica dominicana
Idioma:
En
Revista:
Contraception
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Estados Unidos
País de publicação:
Estados Unidos