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Selective in vitro protection of SIVagm-induced cytolysis by ajoene, [(E)-(Z)-4,5,9-trithiadodeca-1,6,11-triene-9 oxide].
Walder, R; Kalvatchev, Z; Apitz-Castro, R.
Afiliação
  • Walder R; Centro de Microbiología y Biología Celular, Instituto Venezolano de Investigaciones Científica, Caracas, Venezuela.
Biomed Pharmacother ; 52(5): 229-35, 1998.
Article em En | MEDLINE | ID: mdl-9755820
We studied the effect of synthetic ajoene on simian immunodeficiency virus (SIVagm)-mediated cell fusion and subsequent virus-induced cytolysis. Our data indicate that this compound is a strong antifusion agent with a 50% syncytium inhibitory concentration (SIC50%) value of about 2.9 microM. We suggest that ajoene interacts with the cell-specific integrin molecules and sterically hinders the association between fusion (or other co-receptors) and the CD4-gp120 complex at the cell surface of SIV-infected cells. Although ajoene was maximally effective in suppressing syncytium formation during the early period (ie, up to 6 h) of the fusion process, when the compound was recurrently added to the co-cultures, the inhibitory effect was regained and further cell death was markedly delayed. This indicates that ajoene was also effective after the initial cell-to-cell contact stage. These data suggest that ajoene may be a promising approach for the treatment of SIV/human immunodeficiency virus (HIV) infections.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Extratos Vegetais / Células Gigantes / Sobrevivência Celular / Vírus da Imunodeficiência Símia / Dissulfetos Limite: Humans Idioma: En Revista: Biomed Pharmacother Ano de publicação: 1998 Tipo de documento: Article País de afiliação: Venezuela País de publicação: França
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Extratos Vegetais / Células Gigantes / Sobrevivência Celular / Vírus da Imunodeficiência Símia / Dissulfetos Limite: Humans Idioma: En Revista: Biomed Pharmacother Ano de publicação: 1998 Tipo de documento: Article País de afiliação: Venezuela País de publicação: França