Your browser doesn't support javascript.
loading
Molecular and genetic analysis of iron uptake proteins in the brazilian purpuric fever clone of Haemophilus influenzae biogroup aegyptius.
Smoot, L M; Bell, E C; Paz, R L; Corbin, K A; Hall, D D; Steenbergen, J N; Harner, A C; Actis, L A.
Afiliação
  • Smoot LM; Department of Microbiology, Miami University, Oxford, OH 45056, USA.
Front Biosci ; 3: D989-96, 1998 Sep 01.
Article em En | MEDLINE | ID: mdl-9727086
Haemophilus influenzae biogroup aegyptius (H. aegyptius) is the etiological agent of Brazilian purpuric fever (BPF), a recently described pediatric disease that is often fatal. The vascular destruction that occurs in this disease is a distinctive trait, and little is known about the mechanism(s) of the overwhelming purpura fulminans that causes the high mortality associated with this pediatric infection. Iron is an essential micronutrient for nearly all living cells, and the mechanisms used by bacteria to acquire and internalize iron are often associated with virulence. Therefore, the focus of our studies is the molecular characterization of the iron uptake system used by H. aegyptius. Specifically, we are investigating the high-affinity transferrin binding proteins in the bacterial outer membrane, components of ABC transporter systems, and a possible regulatory mechanism for the genes encoding these proteins. A detailed understanding of the molecular nature of the regulatory genetic components and proteins involved in the acquisition of iron will broaden the knowledge of the pathogenesis of the disease caused by H. aegyptius and will also lead to a better understanding of the nature of other infections that affect the vascular system.
Assuntos
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vasculite por IgA / Receptores da Transferrina / Haemophilus influenzae / Ferro Tipo de estudo: Prognostic_studies País/Região como assunto: America do sul / Brasil Idioma: En Revista: Front Biosci Assunto da revista: BIOLOGIA Ano de publicação: 1998 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vasculite por IgA / Receptores da Transferrina / Haemophilus influenzae / Ferro Tipo de estudo: Prognostic_studies País/Região como assunto: America do sul / Brasil Idioma: En Revista: Front Biosci Assunto da revista: BIOLOGIA Ano de publicação: 1998 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos