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A double-blind trial of four medications to treat severe premenstrual syndrome.
Diegoli, M S; da Fonseca, A M; Diegoli, C A; Pinotti, J A.
Afiliação
  • Diegoli MS; Department of Gynecology and Obstetrics, University of São Paulo, Brazil.
Int J Gynaecol Obstet ; 62(1): 63-7, 1998 Jul.
Article em En | MEDLINE | ID: mdl-9722128
OBJECTIVE: To determine the efficacy of fluoxetine (10 mg), alprazolam, propanolol and pyridoxine in the treatment of severe premenstrual syndrome (PMS). METHOD: One-hundred and twenty women were divided into four groups of 30 patients. Patients were submitted to a randomized, double-blind, placebo-controlled treatment and were given 3 months of placebo and 3 months of active drug. The active drug was pyridoxine (300 mg/day) in group 1; alprazolam (0.75 mg/day) in group 2; fluoxetine (10 mg/day) in group 3; and propanolol (20 mg/day and 40 mg during the menstrual period) in group 4. RESULTS: Fluoxetine in 10-mg doses obtained a mean reduction of 65.4% in symptoms, followed by propanolol (58.7%), alprazolam (55.6%), pyridoxine (45.3%) and placebo (39.4-46.1%). CONCLUSION: Fluoxetine in 10-mg doses presented the best results for treating premenstrual syndrome.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridoxina / Ansiolíticos / Síndrome Pré-Menstrual / Alprazolam / Fluoxetina / Inibidores Seletivos de Recaptação de Serotonina Tipo de estudo: Clinical_trials Limite: Female / Humans Idioma: En Revista: Int J Gynaecol Obstet Ano de publicação: 1998 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridoxina / Ansiolíticos / Síndrome Pré-Menstrual / Alprazolam / Fluoxetina / Inibidores Seletivos de Recaptação de Serotonina Tipo de estudo: Clinical_trials Limite: Female / Humans Idioma: En Revista: Int J Gynaecol Obstet Ano de publicação: 1998 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos