IgA B and T cells in the intestinal Villi of immunodeficient rats orally treated with thymomodulin.
Acta Physiol Pharmacol Ther Latinoam
; 48(2): 89-92, 1998.
Article
em En
| MEDLINE
| ID: mdl-9695880
Previous studies on the effect of the oral administration of bacterial immunomodulators (1M-104 and RN-301) during the protein free diet period, have shown an increase on B and T cell gut repopulation, accompanied by IgA antibody production. The usefulness of oral administration of the immunomodulator thymomodulin (TmB) during the protein refeeding period was investigated. TmB allowed the recovery of a normal repopulation of gut lamina propria with IgA B and CD5 T cells and decreases to control values the number of activated intraepithelial lymphocytes (CD25+ T cell subset). Therefore, the oral administration of TmB may be useful as a therapeutic agent as it seems to improve the repopulation of intestinal villi with immunocompetent cells. Also, it seems to regulate the immunosurveillance at the epithelium level as it increases the CD5+ T cells but decreases the activated ones.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Deficiência de Proteína
/
Extratos do Timo
/
Imunoglobulina A
/
Linfócitos B
/
Linfócitos T
/
Adjuvantes Imunológicos
/
Intestinos
Limite:
Animals
Idioma:
En
Revista:
Acta Physiol Pharmacol Ther Latinoam
Assunto da revista:
FARMACOLOGIA
/
FISIOLOGIA
/
TERAPEUTICA
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Argentina
País de publicação:
Argentina