Escapable and inescapable stress differentially and selectively alter extracellular levels of 5-HT in the ventral hippocampus and dorsal periaqueductal gray of the rat.
Brain Res
; 797(1): 12-22, 1998 Jun 22.
Article
em En
| MEDLINE
| ID: mdl-9630480
The effects of escapable and yoked inescapable electric tailshocks on extracellular levels of serotonin (5-HT) in the ventral hippocampus and dorsal periaqueductal gray (dPAG) were measured by in vivo microdialysis. Inescapable, but not escapable shock increased extracellular 5-HT in the ventral hippocampus relative to restrained controls. Basal levels of 5-HT were elevated 24 h after inescapable shock, and previously inescapably shocked subjects exhibited an exaggerated 5-HT response to 2 brief footshocks. In contrast, escapable, but not inescapable shock, increased extracellular 5-HT in the dPAG, increased basal 5-HT in the dPAG 24 h later, and led to an enhanced 5-HT response to subsequent brief footshock.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estresse Fisiológico
/
Substância Cinzenta Periaquedutal
/
Serotonina
/
Hipocampo
Limite:
Animals
Idioma:
En
Revista:
Brain Res
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Venezuela
País de publicação:
Holanda