Effects of long-term low-dose mifepristone on reproductive function in women.
Hum Reprod
; 13(4): 793-8, 1998 Apr.
Article
em En
| MEDLINE
| ID: mdl-9619526
ABSTRACT
PIP: Low-dose antiprogestin administration has been proposed as a new contraceptive modality that interferes with endometrial receptivity without disturbing ovarian function. To explore this potential, the effects on the menstrual cycle of 1 mg/day of mifepristone for 150 days were assessed in 21 surgically sterilized women from Santiago, Chile. Control cycles were biphasic in all 21 women and ovulatory in 20 women. Luteal phase progesterone concentrations were observed in 36 of the 60 treatment months (1, 3, and 5) assessed. The proportion of ovulatory cycles was highest during month 1 and decreased progressively with treatment. 40% of treatment cycles were monophasic and bleeding cyclicity was altered in 57%. Prolonged inter-bleeding intervals or no bleeding occurred in monophasic cycles. Endometrial morphology was altered in all cases, regardless of the occurrence of luteal activity. Increased endometrial thickness and dilated glands were recorded in 25% and 34%, respectively, of the monophasic cycles. These findings suggest that 1 mg of mifepristone interferes with endometrial development while allowing biphasic ovarian cycles and regular bleeding. Whether these endometrial alterations are sufficient to prevent implantation remains to be established. The long-term effect of prevention of ovarian cyclicity and the associated increased endometrial growth recorded in some women require further investigation.
Palavras-chave
Americas; Biology; Chile; Clinical Research; Contraception; Contraception Research; Contraceptive Mode Of Action; Developing Countries; Endocrine System; Endometrial Effects; Endometrium; Family Planning; Genitalia; Genitalia, Female; Hormone Antagonists; Hormones; Latin America; Menstrual Cycle; Menstruation; Ovarian Effects; Ovary; Ovulation Suppression; Physiology; Reproduction; Research Methodology; Research Report; Ru-486--administraction and dosage; South America; Urogenital System; Uterus
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Reprodução
/
Mifepristona
/
Anticoncepcionais Orais Sintéticos
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Hum Reprod
Assunto da revista:
MEDICINA REPRODUTIVA
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Chile
País de publicação:
Reino Unido