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Different effects of phorbol ester derivates on human immunodeficiency virus 1 replication in lymphocytic and monocytic human cells.
Kalvatchev, Z; Walder, R; Garzaro, D.
Afiliação
  • Kalvatchev Z; Laboratorio de Virus Animales, Instituto Venezolano de Investigaciones Científicas, Caracas, Venezuela.
Acta Virol ; 41(5): 289-92, 1997 Oct.
Article em En | MEDLINE | ID: mdl-9607083
The mode of action of the phorbol 12,13-dibutyrate (PDBu) and phorbol 12-myristate 13-acetate (PMA) on the human immunodeficiency virus 1 (HIV-1) replication in human lymphocytes and monocytes was studied. PDBu and PMA appear to have similar effects on the regulation of HIV-1 replication in acutely infected cells. Here we show a significantly increased replication of HIV-1 induced by PDBu and PMA in Molt-4 and Jurkat cells, but a reduced replication in THP-1 and U-937 cells. Moreover, quantitatively different activity of the two derivatives in relation to HIV-1 replication was observed. PDBu proved to be a stronger stimulator or suppressor of HIV-1 replication as compared to PMA. Although the precise mechanism of the activation of HIV-1 replication by phorbol ester derivatives is not clear, it can be assumed that the hydrophilycity of PDBu may cause its stronger effect.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acetato de Tetradecanoilforbol / Linfócitos / Monócitos / Dibutirato de 12,13-Forbol / HIV-1 Limite: Humans Idioma: En Revista: Acta Virol Ano de publicação: 1997 Tipo de documento: Article País de afiliação: Venezuela País de publicação: Eslováquia
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acetato de Tetradecanoilforbol / Linfócitos / Monócitos / Dibutirato de 12,13-Forbol / HIV-1 Limite: Humans Idioma: En Revista: Acta Virol Ano de publicação: 1997 Tipo de documento: Article País de afiliação: Venezuela País de publicação: Eslováquia