[Human papillomavirus, neonatal giant cell hepatitis and biliary duct atresia]. / Virus papiloma humano, hepatitis gigantocelular neonatal y atresia de vías biliares.
Acta Gastroenterol Latinoam
; 28(1): 27-31, 1998.
Article
em Es
| MEDLINE
| ID: mdl-9607071
We previously recognized the presence of HPV-DNA in cases of idiopathic neonatal giant cell hepatitis (INGCH) and extrahepatic biliary duct atresia (EBDA) in archivated tissue using the PCR technique. In order to investigate a possible vertical transmission we looked for the presence of HPV-DNA in cervical swabs in the mothers along with formalin-fixed paraffin-embedded hepatic tissue from 3 infants with INGCH and 4 patients with EBDA by nested-PCR. Cervical smears showed koilocytosis consistent with HPV infection in 2 cases. Delivery was vaginal except for one that was by cesarean section. All infants were males. Amplification of HPV-DNA was demonstrated in all cases, the types being concordant in infants and mothers. Although this is a small group, the findings appear in line with previous data. The presence of the same type of HPV-DNA in the infants' livers and their mothers' cervical swabs is another argument supporting the possibility of vertical transmission of the virus.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Papillomaviridae
/
Atresia Biliar
/
Células Gigantes
/
Hepatite
Limite:
Female
/
Humans
/
Infant
/
Male
/
Newborn
Idioma:
Es
Revista:
Acta Gastroenterol Latinoam
Ano de publicação:
1998
Tipo de documento:
Article
País de publicação:
Argentina