[Cerebral toxoplasmosis and AIDS in Martinique]. / Toxoplasmose cérébrale et SIDA à la Martinique.
Med Trop (Mars)
; 57(3): 259-61, 1997.
Article
em Fr
| MEDLINE
| ID: mdl-9513153
This study was carried out in 60 AIDS patients who presented toxoplasma encephalitis in Martinique (French West Indies). Diagnosis was based on a combination of fever, neurologic signs, and characteristic CT-scan images in patients with positive HIV serology. There were 46 males and 14 females with a mean age of 40 years. The mode of transmission was heterosexual in most cases (68.3%). The incidence of drug-related transmission was low (6.7%). Neurotoxoplasmosis was the most frequent presenting symptom of AIDS (53.3%) followed by esophageal candidosis (20%) and pneumocystosis (10%). Clinical symptoms were headache (56.5%), fever (48.3%), hemiparesia (36.6%), and confusion (36.6%). CT-scan showed most lesions to be multiple (70%), hypodense (89%), and subject to contrast uptake (93%). Mean lymphocyte level was 1128/mm3 with 88 CD4/mm3 and a CD4-to-CD8 ratio of 0.14. Conventional treatment using a combination of pyrimethamine and sulfadiazine led to skin rash and neutropenia and had to be discontinued in 30% of cases. Clinical symptoms and mean survival (327 days) were the same as comparable findings from Europe and North America.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Toxoplasmose Cerebral
/
Infecções Oportunistas Relacionadas com a AIDS
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Prognostic_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Caribe
/
Martinica
Idioma:
Fr
Revista:
Med Trop (Mars)
Assunto da revista:
MEDICINA TROPICAL
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
França
País de publicação:
França