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[Cerebral toxoplasmosis and AIDS in Martinique]. / Toxoplasmose cérébrale et SIDA à la Martinique.
Bourée, P; Dumazedier, D; Magdeleine, C; Sobesky, G.
Afiliação
  • Bourée P; Département des Maladies Parasitaires et Tropicales, Hôpital Bicêtre, Kremlin-Bicêtre, France.
Med Trop (Mars) ; 57(3): 259-61, 1997.
Article em Fr | MEDLINE | ID: mdl-9513153
This study was carried out in 60 AIDS patients who presented toxoplasma encephalitis in Martinique (French West Indies). Diagnosis was based on a combination of fever, neurologic signs, and characteristic CT-scan images in patients with positive HIV serology. There were 46 males and 14 females with a mean age of 40 years. The mode of transmission was heterosexual in most cases (68.3%). The incidence of drug-related transmission was low (6.7%). Neurotoxoplasmosis was the most frequent presenting symptom of AIDS (53.3%) followed by esophageal candidosis (20%) and pneumocystosis (10%). Clinical symptoms were headache (56.5%), fever (48.3%), hemiparesia (36.6%), and confusion (36.6%). CT-scan showed most lesions to be multiple (70%), hypodense (89%), and subject to contrast uptake (93%). Mean lymphocyte level was 1128/mm3 with 88 CD4/mm3 and a CD4-to-CD8 ratio of 0.14. Conventional treatment using a combination of pyrimethamine and sulfadiazine led to skin rash and neutropenia and had to be discontinued in 30% of cases. Clinical symptoms and mean survival (327 days) were the same as comparable findings from Europe and North America.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Toxoplasmose Cerebral / Infecções Oportunistas Relacionadas com a AIDS Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Prognostic_studies Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: Caribe / Martinica Idioma: Fr Revista: Med Trop (Mars) Assunto da revista: MEDICINA TROPICAL Ano de publicação: 1997 Tipo de documento: Article País de afiliação: França País de publicação: França
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Toxoplasmose Cerebral / Infecções Oportunistas Relacionadas com a AIDS Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Prognostic_studies Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: Caribe / Martinica Idioma: Fr Revista: Med Trop (Mars) Assunto da revista: MEDICINA TROPICAL Ano de publicação: 1997 Tipo de documento: Article País de afiliação: França País de publicação: França