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Molecular epidemiology of autoimmune thyroid disease.
Dorman, J; Kramer, M K; O'Lear, L A; Burke, J P; McCanlies, E; McCarthy, B J; Trucco, M; Swan, J S; Steenkiste, A R; Koehler, A N; Foley, T P.
Afiliação
  • Dorman J; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA.
Gac Med Mex ; 133 Suppl 1: 97-103, 1997.
Article em En | MEDLINE | ID: mdl-9504111
This paper presents preliminary data regarding the prevalence and risk factors for autoimmune thyroid disease in IDDM probands ascertained from the Children's Hospital of Pittsburgh IDDM Registry for 1950-1965 (n = 669). Living IDDM probands who participated in the 1990 follow-up survey (n = 380) were recruited for the Familial Autoimmune and Diabetes Study. Siblings and parents were also invited to participate. To date, 255 IDDM probands and 597 parents and siblings have been evaluated. The diagnosis of autoimmune thyroid disease was based on a clinical evaluation, medical history, and laboratory determinations. Graves disease was rare in this cohort (n = 5). However, Hashimoto's thyroiditis was common among women. Prevalence rates ranged from 54% for IDDM women age < 40 years to 75% for those > 50 years. Corresponding age-specific estimates for female relatives were 22% and 44%, respectively. Approximately one-half of the Hashimoto's individuals were euthyroid; they were more likely to have other autoantibodies and a positive family history than those who were hypothyroid or had no thyroid disease. Genetic analyses revealed a 2-fold increase in DQA1*0501-DQB1*0201 among the Hashimoto's compared to the non-Hashimoto's haplotypes. These findings suggested that Hashimoto's thyroiditis was common in IDDM families, which may be due, in part, to common disease susceptibility genes.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Autoimunes / Tireoidite Autoimune / Diabetes Mellitus Tipo 1 Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prevalence_studies / Risk_factors_studies / Screening_studies Limite: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Male / Middle aged País/Região como assunto: America do norte Idioma: En Revista: Gac Med Mex Ano de publicação: 1997 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: México
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Autoimunes / Tireoidite Autoimune / Diabetes Mellitus Tipo 1 Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prevalence_studies / Risk_factors_studies / Screening_studies Limite: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Male / Middle aged País/Região como assunto: America do norte Idioma: En Revista: Gac Med Mex Ano de publicação: 1997 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: México