Hepatitis G virus infection in Amerindians and other Venezuelan high-risk groups.
J Clin Microbiol
; 36(2): 470-4, 1998 Feb.
Article
em En
| MEDLINE
| ID: mdl-9466761
Recently, a new virus related to flaviviruses, the hepatitis G virus (HGV), or GBV-C virus, was discovered as a putative blood-borne human pathogen. HGV RNA (NS5 region) was amplified by reverse transcription-nested PCR in the sera of 6 of 64 (9%) hemodialysis patients; 2 of 80 (2.5%) West Yukpa Amerindians, a population with a high rate of HBV infection but negative for HCV infection; and 1 patient with an acute episode of non-A, non-B, non-C hepatitis (NABCH). The patterns of single-strand conformation polymorphism of the amplified products were unique among different specimens and similar on follow-up for hemodialysis patients. All patients tested remained HGV RNA positive 1 and 2 years later, without major sequence variation, except for the NABCH patient, for whom a double infection and an apparent clearance of the original dominant variant was observed after 2 years. The sequences of the NS5 amplified products demonstrated 85 to 90% identity with other reported HGV sequences.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
RNA Viral
/
Flaviviridae
/
Hepatite Viral Humana
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Risk_factors_studies
Limite:
Humans
País/Região como assunto:
America do sul
/
Venezuela
Idioma:
En
Revista:
J Clin Microbiol
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Venezuela
País de publicação:
Estados Unidos