N-aralkyl substitution of 2-aminoindans. Synthesis and their inotropic and chronotropic activity in isolated guinea pig atria.
Arzneimittelforschung
; 47(11): 1208-10, 1997 Nov.
Article
em En
| MEDLINE
| ID: mdl-9428975
Amino substitution of rigid forms of dopamine 4,5-dihydroxy-2-aminoindan and 5,6-dihydroxy-2-aminoindan with aralkyl functionalities were carried out to investigate the role of such structural modifications upon cardiac inotropic-chronotropic activity. Compounds synthesized demonstrated a modest inotropic selectivity, while one of them, described as 5,6-dihydroxy-N-[2-(4-hydroxyphenyl)-1-methylethyl]-2-aminoindan hydrobromide 17, showed a marked inotropic action on isolated heart tissue.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cardiotônicos
/
Frequência Cardíaca
/
Indanos
/
Contração Miocárdica
Limite:
Animals
Idioma:
En
Revista:
Arzneimittelforschung
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Venezuela
País de publicação:
Alemanha