Cytotoxicity of a low molecular weight fraction from Aloe vera (Aloe barbadensis Miller) gel.
Toxicon
; 35(9): 1423-30, 1997 Sep.
Article
em En
| MEDLINE
| ID: mdl-9403965
The cytotoxicity of a low mol. wt fraction (LMWF) obtained from Aloe vera gel was determined by two different assays. Firstly, exposure of monolayers of chicken fibroblasts to LMWF induced disruption of intercellular junctions and detachment of individual cells from the bottom of the flask, with formation of cell-free gaps in the monolayer. Secondly, LMWF inhibited the production of reactive oxygen species by human polymorphonuclear leukocytes stimulated by zymosan, as followed by luminol-dependent chemiluminescence. The toxic activity of LMWF was compared to that of sodium dodecyl sulfate (a well-known toxic substance), aloe-emodin and aloin (an anthraquinone and its precursor present in Aloe vera cortex) using the chemilumescence assay, and was found to be of similar potency to these toxic substances on a weight-to-weight basis. These results confirm that Aloe vera gel contains toxic low mol. wt compounds, and every effort must be made to limit the amount of these toxins in the commercially prepared Aloe vera gel products.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plantas Medicinais
/
Aloe
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Toxicon
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Venezuela
País de publicação:
Reino Unido