How melatonin interacts with lipid bilayers: a study by fluorescence and ESR spectroscopies.
FEBS Lett
; 416(1): 103-6, 1997 Oct 13.
Article
em En
| MEDLINE
| ID: mdl-9369243
ESR spectra of spin labels placed at the membrane surface and at different depths of the bilayer core, and melatonin fluorescence in the presence of lipid vesicles, suggest an average shallow position for the hormone in the membrane. However, according to the melatonin ability to cross lipid bilayers, nitroxides placed deep in the bilayer were able to quench the melatonin fluorescence. Melatonin membrane partition coefficients were calculated for bilayers in different packing states, and similar and rather high values were found. The data presented here may be quite important to the understanding of melatonin physiological actions at the membrane level.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dimiristoilfosfatidilcolina
/
Bicamadas Lipídicas
/
Melatonina
Idioma:
En
Revista:
FEBS Lett
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Reino Unido