Skin biopsy as a nondestructive tool for the toxicological assessment of endangered populations of pinnipeds: preliminary results on mixed function oxidase in Otaria flavescens.
Chemosphere
; 35(8): 1623-35, 1997 Oct.
Article
em En
| MEDLINE
| ID: mdl-9353903
The aim of this study was to develop and validate a method for assessing the toxicological risk of endangered populations of pinnipeds based on a nondestructive biological tool, the skin biopsy specimen. Skin biopsies can be obtained from pinnipeds by anaesthetising the animals and taking a small amount of skin in the anterior flipper area, or by shooting a biopsy dart with a crossbow. Skin biopsy material is suitable for a wide range of chemical and biomarker analysis. Organochlorines and polycyclic aromatic hydrocarbons can be analysed in subcutaneous fat and MFO activity (BPMO), Cyt.P450 isoforms, and DNA damage can be detected in epidermis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Caniformia
/
Hidrocarbonetos Policíclicos Aromáticos
/
Pele
/
Poluentes Químicos da Água
/
Microssomos Hepáticos
/
Focas Verdadeiras
/
Oxigenases de Função Mista
Limite:
Animals
País/Região como assunto:
America do sul
/
Argentina
Idioma:
En
Revista:
Chemosphere
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Itália
País de publicação:
Reino Unido