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[Extensive cerebral venous thrombosis resistant to heparin: local fibrinolysis with urokinase]. / Thrombose veineuse cérébrale étendue résistante à l'héparine: fibrinolyse locale par urokinase.
Smadja, D; Raynaud, M; Mehdaoui, H; Poey, C; Drault, J N; Ridarch, A; Tixier, F; Vernant, J C; Mas, J L.
Afiliação
  • Smadja D; Service de Neurologie, CHU Fort-de-France, Martinique.
Rev Neurol (Paris) ; 153(4): 271-4, 1997 May.
Article em Fr | MEDLINE | ID: mdl-9296147
A 37 year-old man had headaches for 10 days, then a single tonic-clonic seizure and coma due to an extensive cerebral venous thrombosis. In spite of full-dose heparin treatment for 7 days, the clinical picture worsened along with increasing edema on CT-Scan. Direct thrombolytic treatment was then performed using transvenous catheterization and instillation of Urokinase (2.6 MU over 4 days). A near complete repermeabilization of the sinuses was obtained and the patient improved dramatically in a few days. The only adverse effect of Urokinase was hematuria. Based on our experience and review of the literature which includes 26 previous cases, direct thrombolytic therapy appears to be a relatively safe procedure. This treatment should be considered in a patient with extensive dural sinus thrombosis which fails to respond to heparin treatment.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ativadores de Plasminogênio / Ativador de Plasminogênio Tipo Uroquinase / Embolia e Trombose Intracraniana Limite: Adult / Humans / Male Idioma: Fr Revista: Rev Neurol (Paris) Ano de publicação: 1997 Tipo de documento: Article País de afiliação: Martinica País de publicação: França
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ativadores de Plasminogênio / Ativador de Plasminogênio Tipo Uroquinase / Embolia e Trombose Intracraniana Limite: Adult / Humans / Male Idioma: Fr Revista: Rev Neurol (Paris) Ano de publicação: 1997 Tipo de documento: Article País de afiliação: Martinica País de publicação: França