[Extensive cerebral venous thrombosis resistant to heparin: local fibrinolysis with urokinase]. / Thrombose veineuse cérébrale étendue résistante à l'héparine: fibrinolyse locale par urokinase.
Rev Neurol (Paris)
; 153(4): 271-4, 1997 May.
Article
em Fr
| MEDLINE
| ID: mdl-9296147
A 37 year-old man had headaches for 10 days, then a single tonic-clonic seizure and coma due to an extensive cerebral venous thrombosis. In spite of full-dose heparin treatment for 7 days, the clinical picture worsened along with increasing edema on CT-Scan. Direct thrombolytic treatment was then performed using transvenous catheterization and instillation of Urokinase (2.6 MU over 4 days). A near complete repermeabilization of the sinuses was obtained and the patient improved dramatically in a few days. The only adverse effect of Urokinase was hematuria. Based on our experience and review of the literature which includes 26 previous cases, direct thrombolytic therapy appears to be a relatively safe procedure. This treatment should be considered in a patient with extensive dural sinus thrombosis which fails to respond to heparin treatment.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ativadores de Plasminogênio
/
Ativador de Plasminogênio Tipo Uroquinase
/
Embolia e Trombose Intracraniana
Limite:
Adult
/
Humans
/
Male
Idioma:
Fr
Revista:
Rev Neurol (Paris)
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Martinica
País de publicação:
França