Treatment of visceral leishmaniasis in children with liposomal amphotericin B.
J Pediatr
; 131(2): 271-7, 1997 Aug.
Article
em En
| MEDLINE
| ID: mdl-9290615
We used liposomal amphotericin B as first-choice treatment of visceral leishmaniasis in 106 immunocompetent children who acquired the infection in a temperate region of southern Europe (Italy) where Leishmania infantum visceral leishmaniasis is endemic. The aim of the study was to identify the minimum total dose of liposomal amphotericin B needed to cure the infection in children and reduce the period of hospitalization. We conclude that the optimal regimen in immunocompetent children with L. infantum visceral leishmaniasis to be a total dose of 18 mg/kg of liposomal amphotericin B (3 mg/kg per day for 5 days, followed by 3 mg/kg administered as an outpatient regimen on day 10).
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Anfotericina B
/
Leishmaniose Visceral
/
Antiprotozoários
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Adolescent
/
Animals
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
País/Região como assunto:
Europa
Idioma:
En
Revista:
J Pediatr
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Itália
País de publicação:
Estados Unidos