[Pharmacokinetic variations in anticonvulsants in Mexican epileptic women during different stages of the postpartum period]. / Variaciones farmacocinéticas de anticonvulsivantes en mujeres epilépticas mexicanas durante las diferentes etapas del postparto.
Ginecol Obstet Mex
; 65: 163-6, 1997 May.
Article
em Es
| MEDLINE
| ID: mdl-9273324
During pregnancy, there are several physiological changes that influence the kinetics of medication administrated during this time. These physiological changes are not reestablished immediately during delivery; so, its concentration in biologic fluids is different when is administered immediately after delivery, than several weeks after. The purpose in this work was to identify the changes of pharmacocinetics constants for fenitoin and carbamacepine, in epileptic patients. When the same dose is maintained, during different times of postpartum. In 20 Mexican epileptic women, the plasma and milk concentrations of fenitoina during 60 day postpartum and in 14 carbamacepine was determined. In all the patients pharmakocinetics of anticonvulsivant, in each study period (5, 15, 30, 45 y 60 days postpartum). Excretion index of maternal milk was determined. Maximal plasmatic concentration of fentoine had no variation; however, carbamacepine was higher during the late period. There were no differences in the areas under curve and life all the middle of elimination and in excretion index.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fenitoína
/
Complicações na Gravidez
/
Carbamazepina
/
Período Pós-Parto
/
Epilepsia
/
Anticonvulsivantes
Limite:
Animals
/
Female
/
Humans
/
Pregnancy
País/Região como assunto:
Mexico
Idioma:
Es
Revista:
Ginecol Obstet Mex
Ano de publicação:
1997
Tipo de documento:
Article
País de publicação:
México