Syndrome of inappropriate secretion of antidiuretic hormone in nasopharynx carcinoma.

Krmar, R T; Ferraris, J R; Ruiz, S E; Dibar, E; Morandi, A A; Ramirez, J A

Krmar, R T; Ferraris, J R; Ruiz, S E; Dibar, E; Morandi, A A; Ramirez, J A.

Afiliação

Krmar RT; Servicio de Nefrología Pediátrica, Hospital Italiano de Buenos Aires, Argentina.

Pediatr Nephrol ; 11(4): 502-3, 1997 Aug.

Article em En | MEDLINE | ID: mdl-9260257

RESUMO

The syndrome of inappropriate secretion of antidiuretic hormone (ADH) or SIADH has been reported in various disorders. We report a pediatric patient with nasopharynx carcinoma who may have developed a clinical SIADH with severe hyponatremia and generalized seizure during the administration of intravenous hydration. We propose that the inappropriately high plasma level of ADH led to the inability to excrete sufficient amounts of free water during a hyperhydration protocol with a relatively hypotonic fluid, which resulted in acute hyponatremia and central nervous system involvement. To avoid this complication, intravenous hydration before chemotherapy in children with nasopharynx carcinoma should be performed at a slower infusion rate and with a sodium chloride concentration of more than half isotonic.

Assuntos

Síndrome de Secreção Inadequada de HAD/etiologia; Neoplasias Nasofaríngeas/complicações; Criança; Humanos; Masculino

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Nasofaríngeas / Síndrome de Secreção Inadequada de HAD Tipo de estudo: Guideline Limite: Child / Humans / Male Idioma: En Revista: Pediatr Nephrol Assunto da revista: NEFROLOGIA / PEDIATRIA Ano de publicação: 1997 Tipo de documento: Article País de afiliação: Argentina País de publicação: Alemanha

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