Adenosine-1 active ligands: cirsimarin, a flavone glycoside from Microtea debilis.
J Nat Prod
; 60(6): 638-41, 1997 Jun.
Article
em En
| MEDLINE
| ID: mdl-9214739
Several plants collected through different approaches were screened on distinct receptors using ligand-binding studies as bioassay. Extracts of Microtea debilis showed high activity on adenosine A1 receptors. Bioassay-guided fractionation using ligand-binding studies resulted in the isolation of an adenosine A1 active ligand, cirsimarin (cirsimaritin 4'-O-glucoside). GTP did not influence the radioligand inhibition curve of cirsimarin, indicating that this compound is acting as an antagonist at the adenosine-A1 receptors. The use of this plant against "proteinuria" in traditional medicine in Suriname (South America) may be explained by the adenosine A1 antagonistic action of cirsimarin. A series of flavonoids was tested in the same assay, but they were less active. No structure-activity relationship could be observed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Flavonoides
/
Receptores Purinérgicos P1
/
Flavonas
/
Glicosídeos
Limite:
Animals
País/Região como assunto:
America do sul
/
Caribe ingles
/
Suriname
Idioma:
En
Revista:
J Nat Prod
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Bélgica
País de publicação:
Estados Unidos