Laminin-binding proteins in EJ-ras-transformed fibroblasts.

Chammas, R; Jasiulionis, M G; Ventura, A M; Travassos, L R; Brentani, R R

Chammas, R; Jasiulionis, M G; Ventura, A M; Travassos, L R; Brentani, R R.

Afiliação

Chammas R; Ludwig Institute for Cancer Research, São Paulo, Brasil. rchammas@ucsd.edu

Braz J Med Biol Res ; 29(9): 1141-9, 1996 Sep.

Article em En | MEDLINE | ID: mdl-9181057

RESUMO

Malignant transformation is accompanied by changes in cell-matrix interactions. Upon transfection with EJ-ras oncogene, transformed fibroblasts acquired a migratory phenotype towards laminin-1. The increase in integrin expression was responsible for the migratory activity of transformed fibroblasts. In addtion alpha 6 beta 1 integrins, both galectin-3 and an unidentified laminin-binding polypeptide had their expression pattern altered upon transformation. Here, we review these two classes of laminin-binding proteins and their possible roles in cell-laminin interactions.

Assuntos

Transformação Celular Neoplásica/genética; Fibroblastos/imunologia; Genes ras/genética; Laminina/imunologia; Lectinas/imunologia; Neoplasias Mamárias Animais/imunologia; Animais; Humanos; Oncogenes/imunologia

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Mamárias Animais / Transformação Celular Neoplásica / Genes ras / Laminina / Fibroblastos / Lectinas Limite: Animals / Humans Idioma: En Revista: Braz J Med Biol Res Ano de publicação: 1996 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil

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