[Neuronal toxicity of human recombinant interleukin-2 in rats. Morphological and behavioral validation]. / Toxicidad neuronal de la interleucina-2 recombinante humana en ratas. Validación morfoconductual.
Rev Neurol
; 25(139): 452-6, 1997 Mar.
Article
em Es
| MEDLINE
| ID: mdl-9147785
INTRODUCTION AND OBJECTIVE: The memory impairment which accompanies the aging process is a manifestation of diminished cognitive function. This is intimately related to neuropathological and biochemical changes in cholinergic areas of central nervous system (CNS). Cytokines, first described as immunoregulators, are also implied in defense reactions of the brain. Some studies on the action of IL-2 on the CNS suggest an action blocking the release of acetylcholine in the hippocampus. MATERIAL AND METHODS: We have studied the possible central neurotoxic effect of this soluble factor using the chronic intraperitoneal infusion of human recombinant IL-2 (hr-IL 2) to young and old Sprague Dawley rats. RESULTS AND CONCLUSIONS: The results do not show an in vivo action of IL-2 on the cholinergic function but are consistent with the probable role of this cytokine in the senescent cognitive impairment, in particular the age-related loss of spatial memory and/or during the evolution of neurodegenerative related process.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Interleucina-2
Limite:
Animals
Idioma:
Es
Revista:
Rev Neurol
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Cuba
País de publicação:
Espanha