Microsomal and peroxisomal fatty acid oxidation in bile duct ligated rats: a comparative study between liver and kidney.
Gen Pharmacol
; 28(4): 525-9, 1997 Apr.
Article
em En
| MEDLINE
| ID: mdl-9147020
1. Microsomal cytochrome P-450 and peroxisomal fatty acid oxidation was studied in the kidney of rats 7 days after bile duct ligation (BDL) and a comparative study between kidney and liver was done. 2. Only in the liver did cholestasis decrease the cytocrome P-450 content and the peroxisomal fatty acid beta-oxidation, the catalase activity, and the microsomal metabolism of lauric acid and aminopyrine. 3. In contrast, cholestasis did not influence these activities in the kidney. The microsomal and peroxisomal activities studied responded in a coordinate way to cholestasis. 4. These results could suggest the possibility of a cause-and-effect relationship between microsomal cytochrome P-450 and peroxisomal activity.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Catalase
/
Aminopirina
/
Colestase
/
Sistema Enzimático do Citocromo P-450
/
Ácidos Graxos
/
Rim
/
Fígado
Limite:
Animals
Idioma:
En
Revista:
Gen Pharmacol
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Chile
País de publicação:
Reino Unido