A t(9;11) translocation in childhood acute mixed leukemia.

Chauffaille, M L; Yamamoto, M; Odone Filho, V; Almeida, M T; Maluf Júnior, P; Cristofani, L M; Kerbauy, J; Raimondi, S C

Chauffaille, M L; Yamamoto, M; Odone Filho, V; Almeida, M T; Maluf Júnior, P; Cristofani, L M; Kerbauy, J; Raimondi, S C.

Afiliação

Chauffaille ML; Department of Hematology, Escola Paulista de Medicina, São Paulo, Brazil.

Sao Paulo Med J ; 114(2): 1127-30, 1996.

Article em En | MEDLINE | ID: mdl-9077022

RESUMO

We present the case of a child with acute lymphoid leukemia (ALL) who was morphologically classified as FAB L1 (PAS and peroxidase were negative). Remission was achieved with an ALL-type protocol (GBTLI). Five months after the discontinuation of therapy, the patient presented mixed leukemia (CD10, CD19, CD13 and CD33 were positive) with t (9;11) (p21;q23) translocation. Unfortunately, as cytogenetic and immunophenotype studies were not performed at diagnosis, two possibilities could be considered for the relapse; secondary mixed leukemia with clonal chromosome changes, or mixed leukemia from the beginning.

Assuntos

Leucemia Aguda Bifenotípica/genética; Leucemia-Linfoma Linfoblástico de Células Precursoras/genética; Translocação Genética; Criança; Humanos; Cariotipagem; Masculino

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Translocação Genética / Leucemia Aguda Bifenotípica / Leucemia-Linfoma Linfoblástico de Células Precursoras Tipo de estudo: Guideline Limite: Child / Humans / Male Idioma: En Revista: Sao Paulo Med J Assunto da revista: MEDICINA Ano de publicação: 1996 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil

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