Safety, efficacy, and acceptability of medical abortion in China, Cuba, and India: a comparative trial of mifepristone-misoprostol versus surgical abortion.
Am J Obstet Gynecol
; 176(2): 431-7, 1997 Feb.
Article
em En
| MEDLINE
| ID: mdl-9065194
ABSTRACT
PIP: A multi-center comparative study of medical compared to surgical abortion confirmed that medical abortion can be safe, effective, and acceptable in developing countries. A total of 1373 women from medical centers in China, Cuba, and India with pregnancies of 56 days' gestation or less were given the choice of surgical abortion or 600 mg of mifepristone followed after 48 hours by 400 mcg of misoprostol. Since the majority selected medical abortion, researchers in China and Cuba assigned some of these women to the surgical group to equalize the size of the two groups. The surgical abortion failure rates in China, Cuba, and India were 0.4%, 4%, and 0%, respectively, while the failure rates for medical abortion were 8.6%, 16.0%, and 5.2%, respectively. In all sites, both medical failures (an adverse effect resulting in a medically indicated surgical intervention) and acceptability failures (failure to complete the entire regimen) contributed substantially to the gross failure rates for medical abortion. Medical abortion failure rates increased with gestational age. Although cramping, nausea, and vomiting were more frequent among women in the medical abortion group and bleeding was heavier, general assessments of well-being reported at exit interviews did not differ between the two treatment groups at any site. Regardless of abortion method, the majority of women were either satisfied or highly satisfied with the procedure. In all countries, a higher number of medical than surgical abortion patients indicated they would opt again for the same procedure. Neither the bleeding pattern nor the higher failure rate associated with medical abortion justify withholding this option from women in developing countries.
Palavras-chave
Empirical Approach; Genetics and Reproduction; Abortion, Drug Induced; Abortion, Induced; Americas; Asia; Biology; Caribbean; China; Comparative Studies; Cuba; Curettage; Developing Countries; Eastern Asia; Endocrine System; Family Planning; Fertility Control, Postconception; Hormone Antagonists; Hormones; India; Latin America; Misoprostol; North America; Obstetrical Surgery; Physiology; Prostaglandins; Prostaglandins, Synthetic; Research Methodology; Research Report; Ru-486; Southern Asia; Studies; Surgery; Treatment
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Abortivos
/
Aceitação pelo Paciente de Cuidados de Saúde
/
Mifepristona
/
Misoprostol
/
Aborto Induzido
/
Gestantes
/
Países em Desenvolvimento
Tipo de estudo:
Clinical_trials
/
Etiology_studies
/
Risk_factors_studies
Aspecto:
Determinantes_sociais_saude
/
Patient_preference
Limite:
Adult
/
Female
/
Humans
/
Pregnancy
País/Região como assunto:
Asia
/
Caribe
/
Cuba
Idioma:
En
Revista:
Am J Obstet Gynecol
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Estados Unidos
País de publicação:
Estados Unidos