[Effects of Bothrops alternatus venom of Argentina on muscle and different organs in mices]. / Efectos del Veneno de Bothrops alternatus de Argentina Sobre Músculo y Distintos Organos de Ratones.
Acta Physiol Pharmacol Ther Latinoam
; 46(2): 97-102, 1996.
Article
em Es
| MEDLINE
| ID: mdl-8998374
Bothrops alternatus venom was inoculated in gastrocnemius muscle of mice between 18 and 20g. The dose was 50 micrograms in 0.1 ml in ClNa 0.85% solution. Groups of 5 animals were sacrified between 3, 6 and 12 hours after inoculation. Hystopathology was performed with muscle and different organs fixed with Bouin. The venom reproduced a local inflammatory reaction. Histopathology observations of muscle revealed myolytic and coagulative necrosis. There and six hours after inoculation, hepatocellular degeneration and tumefaction in area of central veins was observed. In kidneys there were cortical congestion and hydropic tumefaction of proximal and distal tubules. There were no anormality in heart, lung and brain.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bothrops
/
Músculo Esquelético
/
Venenos de Crotalídeos
/
Rim
/
Fígado
Limite:
Animals
País/Região como assunto:
America do sul
/
Argentina
Idioma:
Es
Revista:
Acta Physiol Pharmacol Ther Latinoam
Assunto da revista:
FARMACOLOGIA
/
FISIOLOGIA
/
TERAPEUTICA
Ano de publicação:
1996
Tipo de documento:
Article
País de publicação:
Argentina