Temporal relationship between Uniplant insertion and changes in cervical mucus.
Contraception
; 54(4): 213-7, 1996 Oct.
Article
em En
| MEDLINE
| ID: mdl-8922874
ABSTRACT
PIP: In Brazil, physicians inserted one single capsule of the nomegestrol acetate contraceptive implant (Uniplant) subcutaneously in the gluteal region of 17 healthy female volunteers (mean age = 24.62 years) when their cervical mucus score was 8-10. They performed cervical mucus examination, sperm penetration test, and transvaginal sonography during the control cycle and during the first cycle of Uniplant use. They took blood samples to measure estradiol, luteinizing hormone (LH), and progesterone. Uniplant contained 55 mg of nomegestrol acetate. The researchers aimed to determine the time between Uniplant insertion and changes in cervical mucus and in the ability of sperm to exhibit forward motility in the cervical mucus. When Uniplant was inserted in the early follicular phase, the preovulatory peaks of estradiol and LH were significantly lower than preinsertion peaks (539.4 vs. 1087.1 pmol/l and 12 vs. 40.4 IU/l, respectively; p 0.01). The lower progesterone levels in the treatment cycle were not significantly different than preinsertion progesterone levels (46.6 vs. 53.8 nmol/l; p = 0.055). Ultrasonography and progesterone levels indicated that 16 of the 17 treatment cycles were ovulatory. Neither cervical mucus nor sperm penetration was affected in the first 12 hours postinsertion. By 24 hours postinsertion, 70.6% of the women exhibited significant changes in both cervical mucus and sperm penetration. At the end of 48 hours, all 17 women had these changes. These findings suggest that Uniplant inserted in the periovulatory phase affects cervical mucus production, sperm penetration, and preovulatory peaks of LH and estradiol but does not affect ovulation.
Palavras-chave
Americas; Biology; Brazil; Cervical Mucus--changes; Cervix; Contraception; Contraception Research; Contraceptive Agents; Contraceptive Agents, Female; Contraceptive Agents, Progestin; Contraceptive Implants; Contraceptive Methods; Contraceptive Mode Of Action; Demographic Factors; Developing Countries; Endocrine System; Estradiol; Estrogens; Family Planning; Genitalia; Genitalia, Female; Gonadotropins; Gonadotropins, Pituitary; Hormones; Inhibition Of Fertilization; Latin America; Luteinizing Hormone; Physiology; Population; Population Dynamics; Research Report; South America; Sperm Transport Inhibition; Time Factors; Urogenital System; Uterus
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Muco do Colo Uterino
/
Congêneres da Progesterona
/
Megestrol
/
Norpregnadienos
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Contraception
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Estados Unidos