Glutathione plays a role in the chick intestinal calcium absorption.
Comp Biochem Physiol A Physiol
; 115(2): 127-32, 1996 Oct.
Article
em En
| MEDLINE
| ID: mdl-8916550
DL-buthionine-S,R-sulfoximine (BSO) administration to vitamin D-deficient chicks treated with cholecalciferol produces a rapid decrease in the Ca2+ transfer from lumen-to-plasma and in the intestinal glutathione content. This response was reversed by addition of glutathione monoester to the intestinal sac. Variables related to the Ca2+ homeostasis such as plasma Ca and P, and intestinal calbindin D28k were not modified by BSO given to vitamin D-deficient chicks treated with cholecalciferol. Intestinal alkaline phosphatase activity, on the contrary, was highly reduced by BSO in vitamin D-deficient chicks treated with vitamin D3. This effect showed time and dose-dependency. Although the mechanism/s of action of BSO on the intestinal Ca absorption is unknown, it is quite possible that thiol groups of protein involved in the Ca2+ transport are affected by the GSH depletion and/or by block of the antioxidant ability of vitamin D3. Thus, reactive oxygen compounds would be increased and, therefore, the Ca2+ movement from lumen to plasma decreases.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Galinhas
/
Cálcio
/
Glutationa
/
Absorção Intestinal
Limite:
Animals
Idioma:
En
Revista:
Comp Biochem Physiol A Physiol
Assunto da revista:
FISIOLOGIA
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Argentina
País de publicação:
Estados Unidos