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Simultaneous administration of 99Tcm-HMPAO-labelled autologous leukocytes and 111In-labelled non-specific polyclonal human immunoglobulin G in bone and joint infections.
de Lima Ramos, P A; Martin-Comin, J; Bajén, M T; Roca, M; Ricart, Y; Castell, M; Mora, J; Puchal, R; Ramos, M.
Afiliação
  • de Lima Ramos PA; Bolsista do Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brasil.
Nucl Med Commun ; 17(9): 749-57, 1996 Sep.
Article em En | MEDLINE | ID: mdl-8895902
The aim of this study was to investigate the ability of 111In-labelled human polyclonal immunoglobulin G (111In-IgG) to localize bone and joint infections compared with 99Tcm-HMAPO-labelled leukocytes (99Tcm-WBC). Thirty-four patients routinely referred for investigation of bone and joint infections were studied. In all patients, a bone scan using 99Tcm-MDP was initially obtained. Subsequently, 99Tcm-WBC and 111In-IgG were simultaneously injected and images obtained at 30 min, 4 h and 24 h post-injection. Diagnostic accuracy was established by bacteriology of specimens obtained by needle aspiration and/or surgery, other imaging methods and clinical follow-up. The images were read by three experienced observers blinded to any other information; the clinical suspicion of infection and the diagnosis were established when two observers agreed. Infection was confirmed in 11 patients. The 99Tcm-WBC scans gave 8 true-positive, 5 false-positive, 18 true-negative and 3 false-negative results. With 111In-IgG, the figures were 7, 6, 17 and 4, respectively. The sensitivity, specificity and accuracy were 72.7%, 78.2% and 76.4% respectively for the labelled leukocytes and 63.6%, 73.9% and 70.6% respectively for 111In-IgG. There was greater agreement between the observers with 99Tcm-WBC than 111In-IgG. In this study, 111In-IgG was less sensitive and less specific than 99Tcm-WBC scintigraphy for the diagnosis of chronic infections, but these differences were not significant. Both tracers appear to be useful in the diagnosis of bone and joint infections. However, our results were less reliable for the diagnosis of an infected prosthesis.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oximas / Doenças Ósseas / Radioisótopos de Índio / Compostos de Organotecnécio / Infecções / Artropatias Tipo de estudo: Diagnostic_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Nucl Med Commun Ano de publicação: 1996 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oximas / Doenças Ósseas / Radioisótopos de Índio / Compostos de Organotecnécio / Infecções / Artropatias Tipo de estudo: Diagnostic_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Nucl Med Commun Ano de publicação: 1996 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido