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Effects of central alpha-adrenergic agonists on hormone-induced 3% NaCl and water intake.
de Paula, P M; Sato, M A; Menani, J V; De Luca Júnior, L A.
Afiliação
  • de Paula PM; Department of Physiological Sciences, School of Dentistry, Paulista State University, Araraquara, Säo Paulo, Brazil.
Neurosci Lett ; 214(2-3): 155-8, 1996 Aug 23.
Article em En | MEDLINE | ID: mdl-8878107
Male rats received intracerebroventricular (ICV) renin (600 ng) or daily subcutaneous injections of deoxycorticosterone (5 mg) to induce 3% NaCl and water intake. Noradrenaline (NOR; 40-160 nmol) and clonidine (CLO; 5-20 nmol) injected ICV induced 70 to 100% inhibition of the intakes. Phenylephrine (PHE; 40-160 nmol) injected ICV induced 60 to 95% inhibition of the intakes. NOR and PHE induced a stronger inhibition on the 3% NaCl intake induced by renin than on the intake induced by deoxycorticosterone (DOC), and CLO did the opposite. CLO was always more effective than PHE to induce inhibition of the intakes. The results suggest that NOR inhibits hormone (angiotensin II, aldosterone)-induced NaCl intake by acting mainly on alpha 2-adrenergic receptors.
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Renina / Agonistas alfa-Adrenérgicos / Desoxicorticosterona / Ingestão de Líquidos Limite: Animals Idioma: En Revista: Neurosci Lett Ano de publicação: 1996 Tipo de documento: Article País de afiliação: Brasil País de publicação: Irlanda
Buscar no Google
Adicionar na Minha BVS
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Renina / Agonistas alfa-Adrenérgicos / Desoxicorticosterona / Ingestão de Líquidos Limite: Animals Idioma: En Revista: Neurosci Lett Ano de publicação: 1996 Tipo de documento: Article País de afiliação: Brasil País de publicação: Irlanda