Differences in basal nocturnal, meal-stimulated, and pentagastrin-stimulated gastric secretion values in a sample of healthy volunteers in basal conditions and under ranitidine influence.
Control Clin Trials
; 17(3): 258-65, 1996 Jun.
Article
em En
| MEDLINE
| ID: mdl-8877261
The gastric secretion values from 16 healthy male volunteers are reported. A nasogastric tube was positioned in the gastric antrum and 10-min gastric secretion samples were obtained hourly by continuous suction. Basal nocturnal, meal-stimulated, and pentagastrin-stimulated gastric acid secretion were measured. Experimental sessions were carried out in control conditions and repeated after a 7-day treatment with placebo and ranitidine (150 mg b.i.d.) in a double-blind procedure. We found six subjects (group I) with basal nocturnal, meal-stimulated, and pentagastrin-stimulated gastric secretion values statistically lower than then rest of the group (group II). Basal nocturnal secretion mean values were 3.99 +/- 6.6 mmol/L (group I) and 59.2 +/- 22.1 mmol/L (group II) (p < 0.01). Meal-stimulated gastric acidity mean values were 33.1 + 17.3 mmol/L (group I) and 65.6 +/- 30.6 mmol/L (group II) (p < 0.05). Pentagastrin-stimulated gastric secretion mean values were 8 +/- 2 mmol/h (group I) and 19.2 +/- 2.7 mmol/h (group II) (p < 0.01). Ranitidine significantly inhibited basal nocturnal, meal-stimulated, and pentagastrin-stimulated gastric acidity values mostly in group II. These results suggest that there are two different patterns of gastric secretion in the healthy male population.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pentagastrina
/
Ranitidina
/
Ingestão de Alimentos
/
Ácido Gástrico
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Control Clin Trials
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
México
País de publicação:
Estados Unidos