Long-lasting functional unresponsiveness induced by a milk-transmitted Mls-1a-like superantigen.
Immunol Lett
; 48(2): 81-9, 1995 Dec.
Article
em En
| MEDLINE
| ID: mdl-8719104
We have recently shown (Piazzon et al. (1994) J. Immunol. 153, 1553) that foster-nursing of BALB/c mice on F1 Mls-1bxa mothers induce the progressive deletion of V beta 6+ and 8.1+ T cells in 50% of the mice. Preceding clonal deletion, a state of functional inactivation of CD4+ T cells to Mls-1a and anti-V beta 6 antibodies was detected in young mice. In the present paper we show that foster-nursing of BALB/c mice on (BALB/cxAKR)FI mothers is able to induce alterations in T cell reactivity in the non-deletor mice. Lymph node cells from foster-nursed mice show a decreased proliferative level against anti-V beta 6 antibodies and a diminished response in MLR and in CTL assays. The proliferative responses to either OVA or Con-A are also reduced. This state of functional inactivation is detected even in 6-month-old foster-nursed mice. Thus, the transmission through milk of the Mls-1a-like superantigen correlates in the non-deletor mice with a long-lasting state of functional inactivation and a decreased immune reactivity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Lactação
/
Antígenos Secundários de Estimulação de Linfócitos
/
Superantígenos
/
Anergia Clonal
Limite:
Animals
Idioma:
En
Revista:
Immunol Lett
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Argentina
País de publicação:
Holanda